By George Karmpoulonis

Indianapolis Colts vs Kansas City Chiefs prediction and odds

Kansas City is a clear 73% favorite in prediction markets, with Indianapolis at 27% after the teams opened Week 1 in opposite fashion. The Chiefs' new run game and attacking defense support that gap, but the Colts have Jonathan Taylor and an extra day of rest to keep the rematch competitive.

By George Karmpoulonis

Seattle Seahawks vs Arizona Cardinals prediction and odds

Seattle is a clear 66% favorite in prediction markets, with Arizona at 35% after both teams opened the season with wins. The Seahawks still have the stronger defensive case, but Sam Darnold's injury and Jacoby Brissett's sharp start make quarterback play the biggest uncertainty.

By George Karmpoulonis

Jacksonville Jaguars vs Denver Broncos prediction and odds

Denver holds a 58% edge in prediction markets, with Jacksonville at 42% after the Jaguars opened the season with a convincing win. The Broncos remain slight favorites at home, but Trevor Lawrence's fast start and Jacksonville's pass rush make this a much tighter matchup than Week 1 form suggests.

By George Karmpoulonis

Pittsburgh Steelers vs New England Patriots prediction and odds

New England enters as a clear 68% favorite, with Pittsburgh at 32% despite the Steelers opening 1-0 and the Patriots starting with a loss. The matchup turns on whether Drake Maye can stay patient and protected against T.J. Watt's front while the Patriots adjust to life without A.J. Brown.

By George Karmpoulonis

Green Bay Packers vs New York Jets prediction and odds

Prediction markets currently make Green Bay clear favorites at 64%, with the Jets at 37% after the teams opened the season in opposite directions. Jordan Love's big-play passing gives the Packers the higher ceiling, but New York's run game and Green Bay's protection issues keep the matchup competitive.

By Chris Old

Washington Commanders at Dallas Cowboys prediction and odds

The Houston Texans are 60% favorites against the Cincinnati Bengals, with two dangerous offenses facing defenses that produced very different Week 1 performances.

By Chris Old

Cincinnati Bengals at Houston Texans prediction and odds

The Houston Texans are 60% favorites against the Cincinnati Bengals, with two dangerous offenses facing defenses that produced very different Week 1 performances.

By Chris Old

Cleveland Browns at Tampa Bay Buccaneers prediction and odds

The Tampa Bay Buccaneers are 80% favorites against the Cleveland Browns, but both teams need a cleaner performance after opening the season with a loss.

By Chris Old

Carolina Panthers at Atlanta Falcons prediction and odds

The Carolina Panthers are slight favorites against the Atlanta Falcons, with Bryce Young's passing form offset by a defense that must respond to Bijan Robinson after a punishing Week 1.

By Chris Old

Miami Dolphins at San Francisco 49ers prediction and odds

The San Francisco 49ers are overwhelming favorites against the Miami Dolphins, but Malik Willis' mobility and Miami's young playmakers give the visitors a route to making the game less comfortable.

By Chris Old

Minnesota Vikings at Chicago Bears prediction and odds

The Chicago Bears are 69% favorites against the Minnesota Vikings after a record-setting opener, although Minnesota's quarterback depth and disruptive defense complicate the market gap.

By Chris Old

New Orleans Saints at Baltimore Ravens prediction and odds

The Baltimore Ravens are 80% favorites against the New Orleans Saints, whose explosive Week 1 comeback showed they can threaten Baltimore if Tyler Shough receives enough protection.

By Chris Old

Las Vegas Raiders at Los Angeles Chargers prediction and odds

The Los Angeles Chargers are 73% favorites against the Las Vegas Raiders, but their untidy opening loss meets a visitor that protected Kirk Cousins and ran the ball well.

By Chris Old

Philadelphia Eagles at Tennessee Titans prediction and odds

The Philadelphia Eagles are 77% favorites against the Tennessee Titans, whose chances depend on protecting Cam Ward and disrupting Jalen Hurts before Philadelphia’s playmakers take control.

By Chris Old

Detroit Lions at Buffalo Bills prediction and odds

The Buffalo Bills are at home against the Detroit Lions, with two of the NFL's deepest offenses set for an early Thursday night test.

By Chris Old

NFC West predictions and odds: Who will win the NFC West in 2026?

The Los Angeles Rams enter as clear NFC West favorites after strengthening a team that was already one win from the Super Bowl, but defending champion Seattle and a loaded San Francisco roster make this one of football's strongest divisions.

By Chris Old

NFC East predictions and odds: Who will win the NFC East in 2026?

Dallas and defending champion Philadelphia are almost inseparable at the top of the NFC East market, while the New York Giants and Washington both enter 2026 with credible reasons to expect significant improvement.

By Chris Old

NFC South predictions and odds: Who will win the NFC South in 2026?

Tampa Bay enters as the NFC South favorite despite missing the playoffs last season, while New Orleans has surged into second and defending champion Carolina begins as only the third choice.