Los Angeles Rams at Arizona Cardinals prediction, start time and team news on Nov. 15, 2026

Arizona's quarterback plan changed on Monday, and so did the Rams' receiving corps. The Rams vs Cardinals game on Sunday, Nov. 15, pairs a 5-4 team on a three-game winning streak with a 3-6 team that may hand a rookie his first NFL start.

Nacua is expected to miss at least a month with MCL and PCL sprains, and Arizona has lost receiver Michael Wilson for the season. That makes this NFC West meeting a test of a Rams defense that ranks eighth in points allowed against an Arizona offense that ranks 26th in points scored.

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When is Rams vs Cardinals?

• Date: Sunday, November 15, 2026
• Kickoff: 4:05 p.m. ET
• Competition: NFL, Week 10
• Home team: Cardinals
• Rams win: 80%
• Cardinals win: 21%

What is the Rams vs Cardinals prediction?

OG.com prediction markets have the Rams as 80% favorites, with the Cardinals at 21%. Market data as of November 10, 2026. For the latest market probabilities, check the OG.com platform.

The case for the Rams starts on defense. They allow 20.1 points per game (eighth in the NFL) and 104 rushing yards per game, and opponents convert 31.6% of their third downs (fourth). Arizona scores 19.8 points per game (26th) and allows 28.3 (31st), so the Rams' defense faces an offense with little margin for a slow start.

The pass rush adds to that edge. Garrett returned from injured reserve in Week 9 with three sacks and a forced fumble in a 20-13 win at Washington. The Rams had just 16 sacks through nine games, tied for 24th in the NFL, so his return gives the front a different look than the one Arizona saw in Week 6.

Arizona still has a route to an upset. It beat Los Angeles 18-16 in that Week 6 game by running for 120 yards and holding the ball for 34:52. The Cardinals' backfield and receiver room look very different now, but a low-possession game keeps the Rams' offense, which will be without its top receiver, from finding rhythm.

Rams vs Cardinals win probabilities

• Rams win: 80%
• Cardinals win: 21%

Prediction market prices are implied probabilities, and these two add up to 101%. The 59-point gap leaves room for movement, because the status of Gardner Minshew's elbow and the timeline for Nacua's return could still change before kickoff.

How could Rams vs Cardinals unfold?

Arizona's best script is a slow one. Running back Tyler Allgeier has 369 rushing yards and two touchdowns this season, including 147 yards in the Week 8 win at Dallas, and tight end Trey McBride has 73 catches for 598 yards. Those two give a young quarterback short, safe options on early downs.

The Rams' script is simpler. Kyren Williams (593 rushing yards, six touchdowns) and Blake Corum have helped the Rams run for 124 yards or more in each of their last three games. Arizona allows 122 rushing yards per game, so a steady ground attack would shorten the day for Beck and keep Garrett and the front rested.

The game can turn on the score. If Arizona falls behind by two possessions, Beck would have to throw into a pass rush with few proven receivers. If Los Angeles stalls early without Nacua, the Cardinals can stay close enough to run the ball and play for field position.

What is the latest team news?

Both teams are still sorting out injuries at the positions that decide this game, and final game designations will come later in the week.

What is the latest on the Rams?

• Puka Nacua (WR): Coach Sean McVay said Monday that Nacua will likely go on injured reserve with MCL and PCL sprains and turf toe. McVay said it's "going to be at least a month," so Nacua isn't expected to play Sunday.
• Davante Adams (WR): Adams has no set return date from a hamstring injury, according to the Associated Press.
• Steve Avila (G): Avila left the Week 9 win with a hamstring injury. McVay said it will take "a little bit of time" for him, while ESPN's injury listing has him questionable.
• Trent McDuffie (CB): ESPN's injury listing has the cornerback out with a back injury, so his status for Sunday is unresolved.
• Jaylen Watson (CB): Watson needs shoulder surgery and will miss the rest of the season, according to McVay.

What is the latest on the Cardinals?

• Gardner Minshew (QB): Minshew is seeking additional medical opinions on a feared torn UCL in his throwing arm, per NFL Network and ESPN. Carson Beck, a third-round rookie, is in line to start, and Arizona signed Josh Johnson from the Bengals' practice squad.
• Michael Wilson (WR): Arizona announced Wilson will miss the rest of the season with a fractured neck.
• Hjalte Froholdt (C): The center is in the concussion protocol, according to the Associated Press.
• Jeremiyah Love (RB): The rookie is on injured reserve with a high ankle sprain and is expected to miss four to five weeks.
• Bam Knight (RB): Knight missed Week 9 in the concussion protocol, and coach Mike LaFleur said he's doing better. ESPN's injury listing has him out.

What could decide Rams vs Cardinals?

Three matchups carry the most weight here, and each starts with a new or missing player.

Can Carson Beck handle the Rams' pass rush?

Arizona has allowed 23 sacks in nine games, about 2.6 per game, and it managed 198 total yards in a 17-3 loss at Seattle last week. Beck would throw to a receiver group behind McBride that has eight catches combined this season, according to Arizona Sports. Against a front with Garrett, quick throws and the run game become Arizona's main protection.

Can the Rams' offense replace Nacua?

Nacua had at least six catches in each of Los Angeles' last five games, including 14 for 150 yards at Washington, where Matthew Stafford targeted him on 19 of 43 attempts. With Adams also out, Tutu Atwell, Tyler Higbee and Colby Parkinson would take on more targets. The offensive line adds another question if Avila can't play, since the Associated Press called him key to the running game.

Who wins the turnover battle?

The Rams have a minus-4 turnover margin and 14 giveaways, tied for 24th in the NFL, and Stafford has thrown nine interceptions. Arizona has just three interceptions this season and eight takeaways overall, so the Cardinals haven't often punished mistakes. A rookie quarterback's first start can change that equation quickly in either direction.

What could move Rams vs Cardinals prediction?

Quarterback news comes first. A confirmation of Minshew's diagnosis, or a surprise decision to keep him on the field, would change Arizona's outlook more than any other development. Injury news is one of the main reasons sports prediction market prices can move during the week.

Designations for Avila and McDuffie, and any update on Adams, will shape how much help Stafford has. Prices can move quickly when that news lands, and limit orders let traders set the price they're willing to accept. Other Week 10 games appear in the daily sports prediction markets schedule.

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