San Francisco 49ers at Dallas Cowboys prediction, start time and team news on Nov. 15, 2026

The 49ers visit the Cowboys on Sunday, Nov. 15, carrying a 7-1 record and the NFL's third-best scoring offense at 29.4 points per game. The Cowboys (4-5) rank sixth at 27.3 points per game, so this Week 10 game pairs two high-scoring offenses with very different defenses.

The Cowboys also have to rebuild their offense on the fly. Tight end Jake Ferguson and running back Tyler Goodson are out for multiple weeks, and receiver George Pickens is questionable. The 49ers have receiver questions of their own, with Mike Evans and Deebo Samuel both listed as questionable.

This article is for informational purposes only and should not be construed as financial or investment advice. Past performance does not guarantee future results.

When is 49ers vs Cowboys?

• Date: Sunday, November 15, 2026
• Kickoff: 4:25 p.m. ET
• Competition: NFL, Week 10
• Home team: Cowboys
• 49ers win: 67%
• Cowboys win: 34%

The game kicks off at AT&T Stadium in Arlington, Texas.

What is the 49ers vs Cowboys prediction?

The 49ers are favorites at 67%, with the Cowboys at 34%, according to OG.com prediction markets. These percentages are implied probabilities, not guaranteed outcomes, and prices in sports prediction markets can change as traders react to new information. Market data as of November 10, 2026. For the latest market probabilities, check the OG.com platform.

The 49ers' case starts on the ground. They average 135 rushing yards per game (7th in the NFL) against a Cowboys defense that allows 147 (31st). The Cowboys gave up 241 rushing yards to the Buccaneers on Oct. 8 and 202 to the Cardinals on Nov. 1, and Christian McCaffrey has 457 yards and nine touchdowns on 102 carries.

That run game also drives their third-down edge. The 49ers convert 51.7% of third downs (2nd), while the Cowboys allow 48.3% (32nd). In the 38-17 win over the Raiders on Nov. 8, the 49ers held the ball for 38:18 and ran for 190 yards, which gave a defense that allows 19.5 points per game (6th) long rests.

The Cowboys' best response is through the air. They rank sixth in passing yards (257 per game), and CeeDee Lamb caught 10 passes for 195 yards in the 27-23 win at the Colts on Nov. 8. If Dak Prescott gets time to throw, the Cowboys can keep pace.

The strongest supported case is 49ers control: rushing, third-down conversions and long drives that keep Prescott and Lamb on the sideline. The Cowboys need the opposite script, with early stops and a passing game that turns possessions into touchdowns.

49ers vs Cowboys win probabilities

• 49ers win: 67%
• Cowboys win: 34%

A 33-point gap puts the 49ers well clear. That fits a team in the top seven of the NFL in scoring offense, rush defense and third-down conversion, facing a defense near the bottom of each. Other Week 10 games are listed in the daily sports prediction markets.

How could 49ers vs Cowboys unfold?

The opening quarter should show which offense controls the pace, and the 49ers have the more repeatable way to get there.

If McCaffrey and Kaelon Black find early room, the Cowboys' offense spends long stretches watching. Yardage alone doesn't prevent that. The Cowboys outgained the Colts 508-271 but converted only five of 16 third downs, and they needed a 29-second touchdown drive late in the fourth quarter to win.

The Cowboys' best route is a game where the 49ers give the ball away. The 49ers' only loss this season, 29-20 at the Falcons on Oct. 25, came with four turnovers despite a 400-295 yardage edge. That game accounts for four of the 49ers' 11 giveaways, and the Cowboys have forced only eight takeaways (tied for 25th), so a repeat is not something they can plan around.

The Cowboys also have to close. According to the AP, they blew a 14-point lead in a 33-30 overtime loss to the Cardinals on Nov. 1 before the comeback win at the Colts.

What is the latest team news?

Both teams will play without starters, and practice reports this week will settle several questionable players.

What is the latest on the 49ers?

• Mike Evans (Achilles) is listed as questionable. Coach Kyle Shanahan said Monday that Evans is not expected to practice Wednesday. NFL Network's Mike Garafolo reported he is "questionable at best."
• Deebo Samuel (hamstring) is questionable and expected to practice Wednesday, according to Shanahan.
• Cornerbacks Deommodore Lenoir (foot) and Renardo Green (back) are questionable and day-to-day. Green had three interceptions across the games against the Seahawks and Raiders.
• Defensive tackle Gracen Halton is out for the season with a broken left ankle, and defensive tackle C.J. West is returning from injured reserve.

What is the latest on the Cowboys?

• Tight end Jake Ferguson (knee) and running back Tyler Goodson (knee) will miss multiple weeks, according to coach Brian Schottenheimer. Luke Schoonmaker is expected to return, and Brevyn Spann-Ford is expected to start at tight end, according to the Dallas Morning News.
• Safety P.J. Locke is out after a second concussion in two weeks.
• George Pickens (hamstring) and cornerback Joey Porter Jr. (ankle) are questionable. Linebackers DeMarvion Overshown (hamstring, back) and Donovan Ezeiruaku (ankle) and returner KaVontae Turpin (ribs) are also working back, and Schottenheimer said decisions will follow this week's practices.

What could decide 49ers vs Cowboys?

Three matchups carry the most weight for the Cowboys' chances of closing the gap.

Can the Cowboys' defense slow the 49ers' run game?

Locke is out and Overshown's status is unresolved, which thins the Cowboys' second level against McCaffrey and Black. Caleb Downs leads the team with 55 tackles and sealed the win at the Colts with an interception, so the Cowboys have a playmaker in the back seven. The front still needs to hold up on early downs.

Can the 49ers' pass rush reach Prescott?

The 49ers have 15 sacks (28th in the NFL), while the Cowboys have allowed 14 (8th fewest). Keion White leads the 49ers with 3.5 sacks, and Halton, who had a sack in two of the last five games, is out for the season. Prescott was sacked four times by the Cardinals and three times by the Colts, so pressure has found him in recent weeks.

Can the 49ers' receivers fill the gaps?

George Kittle has 38 catches for 483 yards, and Jordan Watkins caught four passes for 86 yards and a touchdown against the Raiders. If Evans and Samuel are out or limited, Brock Purdy will lean on those two and the run game. Porter's ankle injury means both secondaries could look different on Sunday.

What could move 49ers vs Cowboys prediction?

Several pending decisions could change the outlook before kickoff.

• 49ers receivers: Practice reports for Evans and Samuel will show how many options Purdy has on Sunday.
• Cowboys receiver and cornerback: Pickens and Porter are in limited practice plans, so the injury report later this week will clarify the Cowboys' passing game and coverage.
• Cowboys running backs: Without Goodson, the Cowboys have Hunter Luepke behind Javonte Williams on the 53-man roster, with Israel Abanikanda and Jashaun Corbin on the practice squad. Schottenheimer said the team is looking at potential moves.
• 49ers cornerbacks: Lenoir and Green are day-to-day, and their availability affects how the 49ers defend Lamb.

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